Sunday, March 31, 2013

15th Annual Spartan Golf Outing and Dinner Auction - in Brookfield ...

The Westmoor Country Club is one of the most premier country clubs, featuring a golf course designed by expert golf architects. The club offers an olympic-sized swimming pool, tennis courts and a banquet and dining area. The executive chef and staff design delicious and creative cuisine that will make every occasion a special one.? Westmoor Country club is located across from the Brookfield Square mall, just off the I-94 interchange.

Source: http://brookfield-wi.patch.com/events/15th-annual-spartan-golf-outing-and-dinner-auction

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Your Priority Should Be Safety When Doing Home Improvement | A2 ...

Injuries that are sustained during a home improvement project are commonly the result of people not putting safety first. If you have been hurt, consider yourself blessed if you are not actually killed, while working on a home project. Most people that get hurt do so by climbing up on a ladder and falling off of it. Roof repair work, such as laying down shingles, is very dangerous even on a low pitch roof.

If you do repairs, and if you use a ladder, you might find yourself falling if it is not properly secure. Most often, people are not setting the ladder up right or decide to reach for something which causes them to fall over. Follow these easy tips and you will be safer than ever when getting things done at home.

Power equipment often features safety accessories. Cutting and grinding power tools have one such feature, which is a safety guard. You want to avoid removing the guards just because it is more convenient. Since there is a lot of flying debris, you could end up hurting your eyes, face or hands. It is critical that you also wear safety glasses. To avoid your hands suffering an injury, you should always put on leather gloves. All this is basic common sense and not hard to remember. Many people end up injured because they choose to ignore these safety aspects.

If you are working on your home on something that involves hammering nails, then here is a nice little tip for you. This suggestion is essential for people who lack experience in working with hammers. Buy or construct something you can use to hold the nail when hammering it. A paperclip can easily be converted into a nail holder. Combs can also be used as nail holders and all you need to do is remove one or two teeth. It?s difficult to understand the pain if you have never hammered a finger.

When dealing with anything that is electrical, you need to use common sense and safety. Dealing with electrical issues in homes that are 50 years or more old can be dangerous. Because of heat and cold, screws can actually become loose via expansion and contraction. Electrical wires that are grounded may be hot or electrical which can cause physical damage if you grab them. If your installation is brittle, it could be a byproduct of lighting fixtures in the same room. If there is no longer any protective barrier between you and exposed wires, get this fixed. Use these suggestions when working with electricity to stay safe.

Most injuries occur because people refuse to implement the proper safety precautions first. If more people would think about their safety, fewer people would be hurt.

Source: http://www.a2eto.org/your-priority-should-be-safety-when-doing-home-improvement/

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Saturday, March 30, 2013

Researchers show stem cell fate depends on 'grip'

Friday, March 29, 2013

The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.

A team of researchers from the University of Pennsylvania has generated new insight on how a stem cell's environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can "grip" the material they are growing in.

The research was conducted by graduate student Sudhir Khetan and associate professor Jason Burdick, along with professor Christopher Chen, all of the School of Engineering and Applied Science's Department of Bioengineering. Others involved in the study include Murat Guvendiren, Wesley Legant and Daniel Cohen.

Their study was published in the journal Nature Materials.

Much research has been done on how stem cells grow on two-dimensional substrates, but comparatively little work has been done in three dimensions. Three-dimensional environments, or matrices, for stems cells have mostly been treated as simple scaffolding, rather than as a signal that influences the cells' development.

Burdick and his colleagues were interested in how these three-dimensional matrices impact mechanotransduction, which is how the cell takes information about its physical environment and translates that to chemical signaling.

"We're trying to understand how material signals can dictate stem cell response," Burdick said. "Rather than considering the material as an inert structure, it's really guiding stem cell fate and differentiation ? what kind of cells they will turn into."

The mesenchymal stem cells the researchers studied are found in bone marrow and can develop into several cell types: osteoblasts, which are found in bone; chondrocytes, which are found in cartilage; and adipocytes, which are found in fat.

The researchers cultured them in water-swollen polymer networks known as hydrogels, which share some similarities with the environments stem cells naturally grow in. These materials are generally soft and flexible ? contact lenses, for example, are a type of hydrogel ? but can vary in density and stiffness depending on the type and quantity of the bonds between the polymers. In this case, the researchers used covalently cross-linked gels, which contain irreversible chemical bonds.

When seeded on top of two-dimensional covalently cross-linked gels, mesenchymal stem cells spread and pulled on the material differently depending on how stiff it was. Critically, the mechanics guide cell fate, or the type of cells they differentiate it into. A softer environment would produce more fat-like cells and a stiffer environment, where the cells can pull on the gel harder, would produce more bone-like cells.

However, when the researchers put mesenchymal stem cells inside three-dimensional hydrogels of varying stiffness, they didn't see these kinds of changes.

"In most covalently cross-linked gels, the cells can't spread into the matrix because they can't degrade the bonds ? they all become fat cells," Burdick said. "That tells us that in 3D covalent gels the cells don't translate the mechanical information the same way they do in a 2D system."

To test this, the researchers changed the chemistry of their hydrogels so that the polymer chains were connected by a peptide that the cells could naturally degrade. They hypothesized that, as the cells spread, they would be able to get a better grip on their surrounding environment and thus be more likely to turn into bone-like cells.

In order to determine how well the cells were pulling on their environment, the researchers used a technique developed by Chen's lab called 3D traction force microscopy. This technique involves seeding the gel with microscopic beads, then tracking their location before and after a cell is removed.

"Because the gel is elastic and will relax back into its original position when you remove the cells," Chen said, "you can quantify how much the cells are pulling on the gel based on how much and which way it springs back after the cell is removed."

The results showed that the stem cells' differentiation into bone-like cells was aided by their ability to better anchor themselves into the growth environment.

"With our original experiment, we observed that the cells essentially didn't pull on the gel. They adhered to it and were viable, but we did not see bead displacement. They couldn't get a grip," Burdick said. "When we put the cells into a gel where they could degrade the bonds, we saw them spread into the matrix and deform it, displacing the beads."

As an additional test, the researchers synthesized another hydrogel. This one had the same covalent bonds that the stem cells could naturally degrade and spread through but also another type of bond that could form when exposed to light. They let the stem cells spread as before, but at the point the cells would begin to differentiate ? about a week after they were first encapsulated ? the researchers further "set" the gel by exposing it to light, forming new bonds the cells couldn't degrade.

"When we introduced these cross-links so they could no longer degrade the matrix, we saw an increase toward fat-like cells, even after letting them spread," Burdick said. "This further supports the idea that continuous degradation is needed for the cells to sense the material properties of their environment and transduce that into differentiation signals."

Burdick and his colleagues see these results as helping develop a better fundamental understanding of how to engineer tissues using stem cells.

"This is a model system for showing how the microenvironment can influence the fate of the cells," Burdick said.

###

University of Pennsylvania: http://www.upenn.edu/pennnews

Thanks to University of Pennsylvania for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 41 time(s).

Source: http://www.labspaces.net/127524/Researchers_show_stem_cell_fate_depends_on__grip__

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New system to restore wetlands could reduce massive floods, aid crops

Thursday, March 28, 2013

Engineers at Oregon State University have developed a new interactive system to create networks of small wetlands in Midwest farmlands, which could help the region prevent massive spring floods and also retain water and mitigate droughts in a warming climate.

The planning tool, which is being developed and tested in a crop-dominated watershed near Indianapolis, is designed to identify the small areas best suited to wetland development, optimize their location and size, and restore a significant portion of the region's historic water storage ability by using only a small fraction of its land.

Using this approach, the researchers found they could capture the runoff from 29 percent of a watershed using only 1.5 percent of the entire area.

The findings were published in Ecological Engineering, a professional journal, and a website is now available at http://wrestore.iupui.edu/ that allows users to apply the principles to their own land.

The need for new approaches to assist farmers and agencies to work together and use science-based methods is becoming critical, experts say. Massive floods and summer droughts have become more common and intense in the Midwest because of climate change and decades of land management that drains water rapidly into rivers via tile drains.

"The lands of the Midwest, which is one of the great food producing areas of the world, now bear little resemblance to their historic form, which included millions of acres of small lakes and wetlands that have now been drained," said Meghna Babbar-Sebens, an assistant professor of civil and construction engineering at Oregon State. "Agriculture, deforestation, urbanization and residential development have all played a role.

"We have to find some way to retain and slowly release water, both to use it for crops and to prevent flooding," Babbar-Sebens said. "There's a place for dams and reservoirs but they won't solve everything. With increases in runoff, what was once thought to be a 100-year flood event is now happening more often.

"Historically, wetlands in Indiana and other Midwestern states were great at intercepting large runoff events and slowing down the flows," she said. "But Indiana has lost more than 85 percent of the wetlands it had prior to European settlement."

An equally critical problem is what appears to be increasing frequency of summer drought, she said, which may offer a solid motivation for the region's farmers to become involved. The problem is not just catastrophic downstream flooding in the spring, but also the loss of water and soil moisture in the summer that can be desperately needed in dry years.

The solution to both issues, scientists say, is to "re-naturalize" the hydrology of a large section of the United States. Working toward this goal was a research team from Oregon State University, Indiana University-Purdue University in Indianapolis, the Wetlands Institute in New Jersey, and the U.S. Environmental Protection Agency. They used engineering principles, historic analysis and computer simulations to optimize the effectiveness of any land use changes, so that minimal land use alteration would offer farmers and landowners a maximum of benefits.

In the Midwest, many farmers growing corn, soybeans and other crops have placed "tiles" under their fields to rapidly drain water into streams, which dries the soil and allows for earlier planting. Unfortunately, it also concentrates pollutants, increases flooding and leaves the land drier during the summer. Without adequate rain, complete crop losses can occur.

Experts have also identified alternate ways to help, including the use of winter cover crops and grass waterways that help retain and more slowly release water. And the new computer systems can identify the best places for all of these approaches to be used.

###

Oregon State University: http://www.orst.edu

Thanks to Oregon State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 38 time(s).

Source: http://www.labspaces.net/127505/New_system_to_restore_wetlands_could_reduce_massive_floods__aid_crops

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Friday, March 29, 2013

Review: Finding Nemo 3D - John Lowdon-NEC - Chronicle Live

Finding Nemo returns to cinemas in 3D format with an added depth of vision that looks stunning

Finding Nemo 3D

*****

Ten years after it was first released, Pixar?s hugely-entertaining comedy swims back into cinemas in the 3D format? ?? and it is still the cinematic catch of the day.

Eye-popping visuals and a superb script, crammed to the gills with laugh-out-loud gags, combine to stunning effect in this wildly inventive fable set beneath the ocean waves.

The conversion to 3D has been lovingly overseen by Pixar supremo John Lasseter and the underwater environments look stunning with the added depth of vision.

You can almost feel fish swimming around you as the camera glides along coral reefs or sinks into the blue beyond and a forest of deadly jellyfish.

Marlin (voiced by Albert Brooks) is a neurotic clownfish who has never recovered emotionally from a barracuda attack which claimed the lives of his wife and all but one of his unborn children.

When his one surviving son? Nemo (Alexander Gould), is plucked from the Great Barrier Reef by a diver and rehoused in a fish tank in a dentist?s waiting room, Marlin embarks on an epic adventure to bring the youngster home.

The clownfish is aided by a friendly blue tang called Dory (Ellen DeGeneres), who suffers from short-term memory loss, travelling through shark-infested waters to be reunited with his boy.

Meanwhile, Nemo hatches a daring escape from the crowded aquarium with the help of the other residents, including a Moorish Idol called Gill (Willem Dafoe), a hygiene-obsessed shrimp called Jacques (Joe Ranft) and a starfish called Peach (Allison Janney).

Finding Nemo is still computer-animated perfection.

Brooks plays his compulsive-obsessive father with sensitivity and dry wit, such as when he frets that none of his children will like him and his wife replies: ?Marlin, there are 400 eggs, I?m pretty sure one of them will like you.?

The rapport between Marlin and Dory is wonderful.

DeGeneres is a hoot as the comic sidekick, repeatedly forgetting who Marlin is and swimming to the surreal conclusion: ?Are ... are you my conscience??

There are dozens of memorable supporting characters, including a surfer dude turtle and a trio of sharks keen to embrace vegetarianism.

?I am a nice, friendly shark,? they chant, ?Not a fish-eating monster. Fish are our friends, not food.?

A great white called Bruce (Barry Humphries) soon changes his tuna when he scents Marlin?s blood.

The animation is jaw-dropping.

Sly visual jokes and rich detail are crammed into every water-logged frame, including a Buzz Lightyear action figure in the dentist?s office.

Before the main feature, there is an uproariously funny new Toy Story short called Partysaurus Rex in which the fun-loving green plastic dinosaur helps a gang of bath toys to stage a rave in a bubble bath.

Pixar certainly knows how to spoil us.

Source: http://www.chroniclelive.co.uk/whats-on/film-tv/review-finding-nemo-3d-2062622

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CA-NEWS Summary

North Korea readies rockets after U.S. show of force

SEOUL/WASHINGTON (Reuters) - North Korea put its missile units on standby on Friday to attack U.S. military bases in South Korea and the Pacific, after the United States flew two nuclear-capable stealth bombers over the Korean peninsula in a rare show of force. North Korean leader Kim Jong-un signed off on the order at a midnight meeting of top generals and "judged the time has come to settle accounts with the U.S. imperialists in view of the prevailing situation", the official KCNA news agency said.

Attempt to end Italy crisis stalls, president mulls next move

ROME (Reuters) - Center-left leader Pier Luigi Bersani has failed in his attempt to find a way out of Italy's political deadlock and President Giorgio Napolitano will now seek another solution, the president's palace said on Thursday. Bersani reported back to Napolitano on Thursday night after being given a mandate almost a week ago to see if he could muster enough support to form a government after the inconclusive election in February.

Iran, North Korea, Syria block U.N. arms trade treaty

UNITED NATIONS (Reuters) - Iran, Syria and North Korea on Friday prevented the adoption of the first international treaty to regulate the $70 billion global conventional arms trade, complaining that it was flawed and failed to ban weapons sales to rebel groups. To get around the blockade, British U.N. Ambassador Mark Lyall Grant sent the draft treaty to Secretary-General Ban Ki-moon and asked him on behalf of Mexico, Australia and a number of others to put it to a swift vote in the General Assembly.

U.S. debates how severely to penalize Russia in human rights spat

WASHINGTON (Reuters) - In a controversy underscoring continued stresses in U.S.-Russia relations, Obama administration officials are debating how many Russian officials to ban from the United States under a new law meant to penalize Moscow for alleged human rights abuses. The debate's outcome, expected in about two weeks, is likely to illustrate how President Barack Obama will handle what critics say is a crackdown on dissent in Russia and set the tone for Washington-Moscow relations in the president's second term.

Mortar kills 15 at Damascus University, Syria says

BEIRUT/ISTANBUL (Reuters) - Fifteen Syrian students were killed when rebel mortar shells hit a Damascus University canteen on Thursday, state-run news agency SANA said, as attacks intensified in the center of the capital. The Syrian Observatory for Human Rights, an opposition monitoring group, said a mortar killed 13 people at the university, without saying who fired the bombs.

South Sudan says 150 killed in battle with rebels

JUBA (Reuters) - More than 150 people have been killed in a battle between South Sudan's army and insurgents in the eastern Jonglei state, officials said on Thursday. The African country's army earlier this month launched an offensive against rebels led by David Yau Yau in Jonglei where the government hopes to search for oil with the help of France's Total.

Kenyatta apologizes for judges gaffe before Kenya poll ruling

NAIROBI (Reuters) - Kenya's president-elect, whose victory is being challenged in the Supreme Court, apologized on Thursday for seeming to dismiss the judges as "some six people" who will "decide something or other". Uhuru Kenyatta, who also faces trial at the International Criminal Court for crimes against humanity over post-election violence five years ago, made the remarks - which went viral on social media - while consulting allies at a resort.

Beleaguered Hollande to reach out to nation on TV

PARIS (Reuters) - With his approval ratings and most of his economic pledges in tatters, French President Francois Hollande will try to convince a disillusioned nation on television on Thursday to keep faith in him to restore the economy to health. Hollande will be grilled in a 45-minute interview on France 2 television, his first such appearance in several months, in a studio whose backdrop and lighting have been prepared by his media team to create a somber mood.

U.S. nominates Breedlove as top NATO commander

WASHINGTON (Reuters) - President Barack Obama nominated U.S. Air Force General Philip Breedlove on Thursday to become NATO's top military commander, a key role as NATO aims to wind down an 11-year-old combat mission in Afghanistan that has tested the resolve of allies. Breedlove, whose nomination was widely expected and endorsed by ambassadors from the 28 NATO allies, would succeed Admiral James Stavridis as NATO's Supreme Allied Commander Europe. His appointment requires U.S. Senate confirmation.

Analysis: Gay marriage rights may carry bigger U.S. tax burden for some

WASHINGTON (Reuters) - If the U.S. Supreme Court strikes down a federal law defining marriage as between a man and woman, the newfound rights for gay married couples may bear something not so welcome - a bigger tax burden. That's because with equality, gay couples will face the same tax woes of many heterosexual couples with similar incomes, including the tax hit known in America as the marriage penalty.

Source: http://news.yahoo.com/ca-news-summary-020317947.html

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Thursday, March 28, 2013

Baumol and Blinders (cont.) (Unqualified Offerings)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/294901996?client_source=feed&format=rss

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Amanda Bynes: What the Heck is Wrong With Her?

Source: http://www.thehollywoodgossip.com/2013/03/amanda-bynes-what-the-heck-is-wrong-with-her/

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Pentagon reduces unpaid leave for civilian workers to 14 days

WASHINGTON (Reuters) - Defense Department civilian employees will have to take 14 days of unpaid leave this year instead of the 22 previously planned after Congress adjusted Pentagon funding in a measure signed by the president this week, an official said on Thursday.

The official, speaking on condition of anonymity, said Defense Secretary Chuck Hagel decided on Wednesday to reduce the number of furlough days facing most of the Pentagon's nearly 800,000 civilian employees to 14 from 22.

The Pentagon had been set to send out furlough notices to employees last week, but delayed the move after Congress passed a measure that funded the government through the end of the fiscal year on September 30. The department said it needed two weeks to see how the measure affected Pentagon finances.

The Defense Department is facing more than $40 billion in budget cuts this year under a process known as sequestration after Congress and the White House failed to reach an agreement on alternative ways to reduce deficits. The new cuts went into effect on March 1.

The Pentagon budget also has been squeezed by a temporary funding mechanism that left it with a shortfall in the main account used to pay civilian personnel.

The funding measure signed by Obama this week kept the budget cuts under sequestration intact but allocated more money to the account used to pay civilians, letting the Pentagon reduce the amount of unpaid leave.

The Pentagon has not announced how many of its nearly 800,000 civilians will have to take unpaid leave, but officials have predicted it could be in the range of 80 percent.

Officials have said civilians supporting the war effort would not be affected, but a final decision on how many other essential personnel would be exempted has not been announced.

(Reporting by David Alexander; Editiing by Vicki Allen)

Source: http://news.yahoo.com/pentagon-reduces-unpaid-leave-civilian-workers-14-days-111401604--business.html

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Details of gene pathways suggest fine-tuning drugs for child brain tumors

Wednesday, March 27, 2013

Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

"By better understanding the basic biology of these tumors, such as how particular mutations in the same gene may respond differently to targeted drugs, we are moving closer to personalized medicine for children with cancer," said the study's first author, Angela J. Sievert, M.D., M.P.H., an oncologist in the Cancer Center at The Children's Hospital of Philadelphia.

Sievert, working with co-first author Shih-Shan Lang, M.D., in the translational laboratory of neurosurgeon Phillip Storm, M.D., and Adam Resnick, Ph.D., published a study ahead of print today in the Proceedings of the National Academy of Sciences.

The study, performed in cell cultures and animals, focused on a type of astrocytoma, the most common type of brain tumor in children. When surgeons can fully remove an astrocytoma (also called a low-grade glioma), a child can be cured. However, many astrocytomas are too widespread or in too delicate a site to be safely removed. Others may recur. So pediatric oncologists have been seeking better options---ideally, a drug that can selectively and definitively kill the tumor with low toxicity to healthy tissue.

The current study focuses on mutations in the BRAF gene, one of the most commonly mutated genes in human cancers. Because the same gene is also mutated in certain adult cancers, such as melanoma, the pediatric researchers were able to make use of recently developed drugs, BRAF inhibitors, which were already being tested with some success against melanoma in adults.

The current study provides another example of the complexity of cancer: in the same gene, different mutations behave differently. Sievert and her colleagues at Children's Hospital were among several research groups who reported almost simultaneously in 2008 and 2009 that mutations in the BRAF gene were highly prevalent in astrocytomas in children. "These were landmark discoveries, because they suggested that if we could block the action of that mutation, we could develop a new, more effective treatment for these tumors," said Sievert.

However, follow-up studies in animal models were initially disappointing. BRAF inhibitors that were effective in BRAF-driven adult melanomas made brain tumors worse?via an effect called paradoxical activation.

Further investigation revealed how tumor behavior depended on which type of BRAF mutation was involved. The first-generation drug that was effective in adult melanoma acted against point mutations in BRAF called V600E alterations. However, in most astrocytomas the mutation in the BRAF gene was different; it produced a fusion gene, designated KIAA1549-BRAF. When used against the fusion gene, the first-generation drug activated a cancer-driving biological pathway, the MAPK signaling cascade, and accelerated tumor growth.

By examining the molecular mechanisms behind drug resistance and working with the pharmaceutical industry, the current study's investigators identified a new, experimental second-generation BRAF inhibitor that disrupted the cancer-promoting signals from the fusion gene, and did not cause the paradoxical activation in the cell cultures and animal models.

This preclinical work result lays a foundation for multicenter clinical trials to test the mutation-specific targeting of tumors by this class of drugs in children with astrocytomas, said Sievert. As this effort progresses, it will benefit from CHOP's commitment to resources and collaborations that support data-intense research efforts.

The direction of brain tumor research over the past several years reflects some of those data-driven advances, says Adam C. Resnick, Ph.D., the senior author of the current paper and principal investigator of the astrocytoma research team in the Division of Neurosurgery at Children's Hospital. "For years, astrocytomas have been lumped together based on similar appearance to pathologists studying their structure, cell shape and other factors," said Resnick. "But our current discoveries show that the genetic and molecular structure of tumors provides more specific information in guiding oncologists toward customized treatments."

Earlier this year, Children's Hospital announced its collaboration with the gene-sequencing organization BGI-Shenzhen in performing next-generation sequencing of pediatric brain tumors at the Joint Genome Center, BGI@CHOP. The center's sophisticated, high-throughput sequencing technology will greatly speed the discovery of specific gene alterations involved in childhood brain cancers.

This genomic discovery program dovetails with the work of the Childhood Brain Tumor Tissue Consortium, a multi-institutional collaboration recently launched by CHOP, with support from the Children's Brain Tissue Foundation. Because even large research centers may not hold enough tumor tissue specimens to power certain research, the consortium pools samples from a group of institutions, providing an important scientific resource for cooperative studies.

"The better we understand the mutational landscape of tumors, the closer we'll be to defining therapies tailored to a patient's specific subtype of cancer," added Resnick.

###

Children's Hospital of Philadelphia: http://www.chop.edu

Thanks to Children's Hospital of Philadelphia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 33 time(s).

Source: http://www.labspaces.net/127476/Details_of_gene_pathways_suggest_fine_tuning_drugs_for_child_brain_tumors

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A new way to lose weight? Changing microbes in guts of mice resulted in rapid weight loss

Mar. 27, 2013 ? Scientists at Harvard may have new hope for anyone who's tried to fight the battle of the bulge.

New research, conducted in collaboration with researchers at Massachusetts General Hospital, has found that the gut microbes of mice undergo drastic changes following gastric bypass surgery. Transfer of these microbes into sterile mice resulted in rapid weight loss. The study is described in a March 27 paper in Science Translational Medicine.

"Simply by colonizing mice with the altered microbial community, the mice were able to maintain a lower body fat, and lose weight -- about 20% as much as they would if they underwent surgery," said Peter Turnbaugh, a Bauer Fellow at Harvard's Faculty of Arts and Sciences (FAS) Center for Systems Biology, and one of two senior authors of the paper.

But as striking as those results were, they weren't as dramatic as they might have been.

"In some ways we were biasing the results against weight loss," Turnbaugh said, explaining that the mice used in the study hadn't been given a high-fat, high-sugar diet to increase their weight beforehand. "The question is whether we might have seen a stronger effect if they were on a different diet."

"Our study suggests that the specific effects of gastric bypass on the microbiota contribute to its ability to cause weight loss and that finding ways to manipulate microbial populations to mimic those effects could become a valuable new tool to address obesity," said Lee Kaplan, director of the Obesity, Metabolism and Nutrition Institute at MGH and the other senior author of the paper.

"We need to learn a good deal more about the mechanisms by which a microbial population changed by gastric bypass exert its effects, and then we need to learn if we can produce these effects -- either the microbial changes or the associated metabolic changes -- without surgery," Kaplan, an associate professor of Medicine at Harvard Medical School, added. "The ability to achieve even some of these effects without surgery would give us an entirely new way to treat the critical problem of obesity, one that could help patients unable or unwilling to have surgery."

While the results were exciting, Turnbaugh warned that it may be years before they could be replicated in humans, and that such microbial changes shouldn't be viewed as a way to lose those stubborn last 10 pounds without going to the gym. Rather, the technique may one day offer hope to dangerously obese people who want to lose weight without going through the trauma of surgery.

"It may not be that we will have a magic pill that will work for everyone who's slightly overweight," he said. "But if we can, at a minimum, provide some alternative to gastric bypass surgery that produces similar effects, it would be a major advance."

While there had been hints that the microbes in the gut might change after bypass surgery, the speed and extent of the change came as a surprise to the research team.

In earlier experiments, researchers had shown that the guts of both lean and obese mice are populated by varying amounts of two types of bacteria, Firmicutes and Bacteroidetes. When mice undergo gastric bypass surgery, however, it "resets the whole picture," Turnbaugh said.

"The post-bypass community was dominated by Proteobacteria and Proteobacteria, and had relatively low levels of Firmicutes," he said. What's more, Turnbaugh said, those changes occurred within a week of the surgery, and weren't short-lived -- the altered gut microbial community remained stable for months afterward.

While the results may hold out the hope for weight loss without surgery, both Turnbaugh and Kaplan warned that future studies are needed to understand exactly what is behind the weight loss seen in mice.

"A major gap in our knowledge is the underlying mechanism linking microbes to weight loss," Turnbaugh said. "There were certain microbes that we found at higher abundance after surgery, so we think those are good targets for beginning to understand what's taking place."

In fact, Turnbaugh said, the answer may not be the specific types of microbes, but a by-product they excrete.

In addition to changes in the microbes found in the gut, researchers found changes in the concentration of certain short-chain fatty acids. Other studies, Turnbaugh said, have suggested that those molecules may be critical in signaling to the host to speed up metabolism, or not to store excess calories as fat.

Going forward, Turnbaugh and Kaplan hope to continue to explore those questions.

"We think such studies will allow us to understand how host/microbial interactions in general can influence the outcome of a given diet," Kaplan said. "To some degree, what we're learning is a comfort for people who have an issue with their weight, because more and more we're learning that the story is more complicated than just how much you exercise and how much you eat."

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The above story is reprinted from materials provided by Harvard University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. P. Liou, M. Paziuk, J.-M. Luevano, S. Machineni, P. J. Turnbaugh, L. M. Kaplan. Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity. Science Translational Medicine, 2013; 5 (178): 178ra41 DOI: 10.1126/scitranslmed.3005687

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/55s2_HYwLsA/130327144124.htm

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Wednesday, March 27, 2013

Minn. train derailment causes oil spill

PARKERS PRAIRIE, Minn. (AP) -- Thousands of gallons of oil leaked onto frozen ground after a train carrying crude from Canada derailed Wednesday in western Minnesota.

The 94-car Canadian Pacific train was headed south near Parkers Prairie when it lost air pressure and went into an emergency braking mode, the Otter Tail County sheriff's office said. Fourteen tankers derailed. Three either leaked or spilled oil. No one was hurt, and a spokesman for the state's pollution control agency said crews were able to control the spill.

An estimated 20,000 to 30,000 gallons leaked onto the ground, Minnesota Pollution Control Agency spokesman Dan Olson said. The spill was contained in a field and ditch in a rural area, and the cold weather helped keep the spill contained and prevented oil from moving down the ditch or into the ground, Olson said.

One heavily damaged car spilled much of its 26,000-gallon load, Olson said. He said the oil was "just oozing out" in the cold.

Because the ground is frozen, there's no threat to water, Olson said. Initial recovery efforts likely will take a day or two, and excavations then will be done to determine if any oil leaked into the soil, he said.

The railroad was cleaning up the spill, Canadian Pacific spokesman Ed Greenberg said.

While the spill appeared to be under control from an ecological standpoint, it could play a role in the politics surrounding the Keystone XL pipeline, which would transport oil from tar sands in Canada to refineries in Texas. Environmentalists have criticized the proposal, saying that a pipeline could be prone to spills and would ensure that the carbon-laden tar sands are fully developed. A recent analysis from the State Department seemed to knock down one of their arguments, by saying that when it comes to global warming, shipping the oil by pipeline would release less pollution than using rail.

Greenberg said he did not know if the oil that spilled was tar sands oil. The train, carrying a mix of cargo, originated in western Canada and was bound for Chicago, he said.

Source: http://news.yahoo.com/train-cars-derail-minnesota-spill-202111375.html

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Chris Brown Talks Losing His 'Dignity' After Rihanna Assault

X singer opens up about his reconciliation with Rihanna, noting 'it's still like we're kids.'
By Jocelyn Vena


Chris Brown and Rihanna
Photo: Getty Images

Source: http://www.mtv.com/news/articles/1704357/chris-brown-rihanna-ryan-seacrest.jhtml

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Tuesday, March 26, 2013

New complex set to open - MadisonJournalTODAY

Madison County?s annual opening day for youth baseball and softball was set for this past weekend ? though the rain put a damper on the day.

Now, soccer won?t be far behind in kicking off its season, with opening day set for April 20. And when those boys and girls put the cleats on and show off their fancy footwork, they?ll do it on brand new fields.

The Brewer-Phillips Sports Complex is now ready to open.

Up to four games can be played simultaneously on the park?s two big fields.

The 10-year-project was funded through the special purpose local option sales tax (SPLOST). ?The good thing about it is we paid it as we went, so we don?t owe anything on it,? said BOC chairman Anthony Dove, who said the county has spent $739,050 on the complex.

Dove said the game of soccer has really exploded in Madison County in recent years, adding that a new park is a great thing for the county.

?It?s one of the biggest, growing sports,? said Dove of soccer. ?And we wouldn?t have been able to keep up with the need without the park.?

Both Dove and current recreation board director Robin Pendleton said former recreation director Dick Perpall deserves thanks for getting the complex rolling. Dove also said the county recreation board deserves praise for its work on the project.

Pendleton said that over 200 Madison County boys and girls will participate in soccer this spring. There will be co-ed leagues for ages 5-6, 7-8, 9-10, 11-13 and 14-17.

Pendleton said that getting the soccer games off of the baseball fields will help improve the condition of those fields.

?This project is years in the making,? said Pendleton. ?It?s good to see fields dedicated to soccer in the county.?

Source: http://www.madisonjournaltoday.com/archives/6019-New-complex-set-to-open.html

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Syrian opposition takes Syria's Arab summit seat

DAMASCUS, Syria (AP) ? Syria's opposition took over the country's seat for the first time at an Arab summit Tuesday in a diplomatic triumph marred by severe divisions in the ranks of the Western-backed opposition alliance.

The opposition's ascension to representing the country at the summit in Qatar, a key backer of the those fighting to topple President Bashar Assad, demonstrated the extent of the regime's isolation two years into a ferocious civil war that the U.N. says has killed an estimated 70,000 people.

In Damascus, the government on Tuesday blasted the Arab League's decision, portraying it as a selling-out of Arab identity to please Israel and the United States.

"The shameful decisions it (Arab League) has taken against the Syrian people since the beginning of the crisis and until now have sustained our conviction that it has exchanged its Arab identity with a Zionist-American one," said an editorial in the Al-Thawra newspaper, a government mouthpiece.

The Qatari ruler, who chaired the summit, said the Syrian opposition deserves "this representation because of the popular legitimacy they have won at home and the broad support they won abroad and the historic role they have assumed in leading the revolution and preparing for building the new Syria."

In a further show of solidarity with anti-Assad forces, the Arab League endorsed the "right of each state" to provide the Syrian people and the Free Syrian Army with "all necessary means to ... defend themselves, including military means."

It was unclear whether the statement would open new weapons channels to fighters. But it would mark a symbolic slap of the U.S. and European allies that have resisted full-scale military aid to the rebels.

Arab League Secretary-General Nabil Elaraby told reporters that the call for "rights" to aid rebels is not an end to diplomatic efforts to solve Syria's crisis, but seeks to provide more "balance" with Assad's superior firepower and aid he is getting from Russia and Iran.

"The right to send more weapons to support the opposition is not an end to political efforts, but this might establish balance between both parties," Elaraby said.

Fighting, meanwhile, raged on in Syria. Rebels barraged Damascus with mortar shells that killed at least three people and wounded dozens in one of the most intensive attacks on the seat of President Bashar Assad's power.

The state news agency also reported that a car bomb exploded near the predominantly Kurdish neighborhood of Rukneddine, killing three people.

The opposition delegation led by Mouaz al-Khatib, the former president of the main opposition alliance ? the Western-backed Syrian National Coalition ? took the seats assigned for Syria at the invitation of Qatar's emir, Sheik Hamad bin Khalifa Al Thani, while other delegates applauded.

Al-Khatib used the forum to call for a greater U.S. role in aiding the rebels and said he had appealed to Secretary of State John Kerry to consider using NATO Patriot anti-missile batteries in Turkey to help defend northern Syria against strikes by Assad's forces.

Asked about al-Khatib's request for Patriots, State Department spokesman Patrick Ventrell said the deployment of the anti-missile batteries to Turkey was a NATO decision with a clear mandate to protect Turkey.

"We've heard some of this before in private," Ventrell told reporters in Washington. "He's now publicly saying this. But again, that's what the NATO mission is."

A NATO official said "the secretary general of NATO has been very clear since the beginning that NATO has no intention of getting militarily involved with Syria. That remains the same."

"Our current deployment of Patriot systems is a defensive action to protect our ally Turkey," said the NATO official in Belgium on condition of anonymity in keeping with the alliance's regulations.

The diplomatic triumph, however, could not conceal the disarray within the top ranks of the opposition and underlined the splits that continue to plague the opposition, complicating U.S. and Western efforts to try to shape the course of the fight to oust Assad.

Besides al-Khatib, the Syrian delegation included Ghassan Hitto, recently elected prime minister of a planned interim government to administer rebel-held areas in Syria, and two prominent opposition figures, George Sabra and Suheir Atassi.

Al-Khatib announced his resignation on Sunday because of what he described as restrictions on his work and frustration with the level of international aid for the opposition. The coalition rejected the resignation and al-Khatib said he would discuss the issue later and represent the opposition at the Qatar summit "in the name of the Syrian people."

Also, Hitto's election as the head of the interim government was rejected by the opposition's military office, which said he was not a consensus figure. Some members have accused Qatar and the Muslim Brotherhood of imposing their will on the Coalition.

Atassi briefly suspended her membership in the coalition after Hitto was elected.

Addressing the gathering, al-Khatib thanked the Arab League for granting the seat to the opposition and lamented the inaction of several foreign governments, which he did not name, toward the Syrian crisis despite the suffering of civilians in his country.

"I convey to you the greetings of the orphans, widows, the wounded, the detained and the homeless," al-Khatib told the gathering in an opulent hall in Doha.

Most of the mortar strikes hit the capital's east side, falling near a school in the Baramkeh neighborhood, the Damascus Hospital, the Law Faculty of Damascus University and the state news agency's own offices.

SANA said one girl and two other civilians were killed.

A government official in Damascus told The Associated Press that four people were killed and 42 wounded. The official spoke on condition of anonymity because he was not authorized to brief the media, and the discrepancy could not immediately be resolved.

Mortar rounds also fell in a number of areas on the city's west side, including the Christian neighborhood of Bab Touma, SANA said.

The agency published photos of a hole in a wall of what appeared to be a school, medics treating blood-stained patients and firemen extinguishing burning cars.

It was not immediately known who fired the mortar shells. Such attacks in the capital have grown more common in recent weeks as rebels have clashed with government troops on the city's east and south sides. While the shelling rarely causes many casualties, it has shattered the aura of normalcy the regime has tried to cultivate in Damascus.

"They think that that through this tactic they can pressure residents to rise up against authorities," said Fayez Sayegh, a member of parliament and a member of the ruling Baath Party. "But on the contrary, this indiscriminate shelling makes people realize that this opposition is nothing but gangs of criminal terrorists."

Meanwhile, anti-regime activists said Syrian troops seized control of a neighborhood in the central city of Homs that is considered a symbol of opposition to Assad's regime.

The Syrian military's recapture of Baba Amr, in Homs, while not strategically important in the civil war, is a symbolic blow to the rebels. The poor, predominantly Sunni neighborhood emerged early in the uprising as a symbol of the rebel movement, first for its protests and later for the armed groups who held it against the regime onslaught.

The seesaw fight for the Homs neighborhood reflects the back-and-forth nature of Syria's civil war. While rebels appear to be gaining ground, their progress is slow and their fighters remain vulnerable to Assad's military superiority.

In other violence Tuesday, the Observatory said that at least 13 charred bodies, including four children and five women, were found on the outskirts of the village of Abil, southwest of Homs city. It said local activists blamed the killings on pro-government gunmen.

The Syrian government does not respond to requests for comment and did not mention the killing in official media.

___

Mroue reported from Beirut. Associated Press writers Brian Murphy in Doha, Ben Hubbard in Beirut, Bradley Klapper in Washington, Tom Wagner in London, and Hamza Hendawi in Cairo contributed to this report.

Source: http://news.yahoo.com/syrian-opposition-takes-syrias-arab-summit-seat-192735251.html

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Pressure Increases On Michael Dell As Carl Icahn Mulls Tie-Up With Blackstone In Bid For PC Company

dell_logo-avatar_200x200Carl Icahn has said he is open to a partnership with Blackstone Group in a move that could make it easier for the rival investors to overtake Michael Dell's $24.4 billion buyout bid for the company he founded, reports Reuters. This means Michael Dell could also potentially lose control of the PC maker he founded when he was 19.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/bdjiANLGp9g/

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OpEdNews - Article: How Noam Chomsky is discussed

(Updated below -- Update II [Sun.])

One very common tactic for enforcing political orthodoxies is to malign the character, "style" and even mental health of those who challenge them. The most extreme version of this was?an old Soviet favorite: to declare political dissidents mentally ill and put them in hospitals. In the US, those who take even the tiniest steps outside of political convention are instantly decreed "crazy," as?happened to the 2002 anti-war version of Howard Dean?and the?current iteration of Ron Paul?(in most cases,?what is actually "crazy" are the political orthodoxies?this tactic seeks to shield from challenge).

This method is applied with particular aggression to those who engage in any meaningful dissent against the society's most powerful factions and their institutions. Nixon White House officials sought to steal the files from Daniel Ellsberg's psychoanalyst's office precisely because they knew they could best discredit his disclosures with irrelevant attacks on his psyche. Identically, the New York Times and partisan Obama supporters have led the way in depicting both?Bradley Manning?and?Julian Assange?as mentally unstable outcasts with serious personality deficiencies. The lesson is clear: only someone plagued by mental afflictions would take such extreme steps to subvert the power of the US government.

A subtler version of this technique is to attack the so-called "style" of the critic as a means of impugning, really avoiding, the substance of the critique. Although Paul Krugman is comfortably within mainstream political thought as a loyal Democrat and a New York Times columnist, his relentless attack against the austerity mindset is threatening to many. As a result, he is barraged with endless, substance-free complaints about his "tone": he is too abrasive, he?does not treat opponents with respect, he?demonizes those who disagree with him, etc. The complaints are usually devoid of specifics to prevent meaningful refutation; one typical example: "[Krugman] often cloaks?his claims in professional authority, overstates them, omits arguments that undermine his case, and is a bit of a bully." All of that enables the substance of the critique to be avoided in lieu of alleged personality flaws.

Nobody has been subjected to these vapid discrediting techniques more than?Noam Chomsky. The book on which I'm currently working explores how establishment media systems restrict the range of acceptable debate in US political discourse, and I'm using Chomsky's treatment by (and ultimate exclusion from) establishment US media outlets as a window for understanding how that works. As a result, I've read a huge quantity of media discussions about Chomsky over the past year. And what is so striking is that virtually every mainstream discussion of him at some point inevitably recites the same set of personality and stylistic attacks designed to malign his advocacy without having to do the work of engaging the substance of his claims. Notably, these attacks?come most frequently?and?viciously from establishment liberal venues, such as when the American Prospect's 2005 foreign policy issue?compared him to Dick Cheney on its cover?(a cover he had framed and now proudly hangs on his office wall).

Last week, Chomsky was?in London to give the annual Edward W. Said lecture, and as always happens when he speaks, the large auditorium was filled to the brim, having sold out shortly after it was announced. The Guardian's Aida Edemariam interviewed him in London and?produced an article, published Saturday morning, that features virtually all of those standard stylistic and personality critiques:

"When he starts speaking, it is in a monotone that makes no particular rhetorical claim on the audience's attention; in fact, it's almost soporific ... Within five minutes many of the hallmarks of Chomsky's political writing, and speaking, are displayed: his anger, his extraordinary range of reference and experience. ... Fact upon fact upon fact, but also a withering, sweeping sarcasm -- the atrocities are 'tolerated politely by Europe as usual'. Harsh, vivid phrases -- the 'hideously charred corpses of murdered infants'; bodies 'writhing in agony' -- unspool until they become almost a form of punctuation.

"You could argue that the latter is necessary, simply a description of atrocities that must be reported, but it is also a method that has diminishing returns. The facts speak for themselves; the adjectives and the sarcasm have the counterintuitive effect of cheapening them, of imposing on the world a disappointingly crude and simplistic argument. 'The sentences,' wrote Larissa MacFarquhar in a brilliant New Yorker profile of Chomsky 10 years ago, 'are accusations of guilt, but not from a position of innocence or hope for something better: Chomsky's sarcasm is the scowl of a fallen world, the sneer of hell's veteran to its appalled naifs' -- and thus, in an odd way, static and ungenerative. ...

"But he answers questions warmly, and seriously, if not always directly -- a surprise, in a way, from someone who has earned a reputation for brutality of argument, and a need to win at all costs. 'There really is an alpha-male dominance psychology at work there,' a colleague once said of him. 'He has some of the primate dominance moves. The staring down. The withering tone of voice.' Students have been known to visit him in pairs, so that one can defend the other. ...

"Chomsky, the son of Hebrew teachers who emigrated from Ukraine and Russia at the turn of the last century, began as a Zionist -- but the sort of Zionist who wanted a socialist state in which Jews and Arabs worked together as equals. Since then he has been accused of antisemitism (due to defending the right to free speech of a French professor who espoused such views, some 35 years ago), and been called, by the Nation, 'America's most prominent self-hating Jew.' These days he argues tirelessly for the rights of Palestinians. ... Does he think that in all these years of talking and arguing and writing, he has ever changed one specific thing?"

So to recap: Chomsky is a sarcastic, angry, soporific, scowling, sneering self-hating Jew, devoid of hope and speaking from hell, whose alpha-male brutality drives him to win at all costs, and who imposes on the world disappointingly crude and simplistic arguments to the point where he is so inconsequential that one wonders whether he has ever changed even a single thing in his 60 years of political work.

Edemariam includes several other passages more balanced and even complimentary. She notes his academic accolades ("One study of the most frequently cited academic sources of all time found that he ranked eighth, just below Plato and Freud"), his mastery of facts, his willingness to speak to hostile audiences, his touching life-long relationship with his now-deceased wife, and his remarkable commitment, even at the age of 84, to personally answering emails from people around the world whom he does not know (when I spoke at a college near Rochester two weeks ago, one of the students, a college senior studying to be a high school social studies teacher, gushed as he told me that he had emailed Chomsky and quickly received a very generous personal reply). She also includes Chomsky's answer to her question about whether he has ever changed anything: a characteristically humble explanation that no one person -- not even Martin Luther King -- can or ever has?by themselves? changed anything.

But the entire piece is infused with these standard personality caricatures that offer the reader an easy means of mocking, deriding and scorning Chomsky without having to confront a single fact he presents. And that's the point: as?this 9-minute Guardian video excerpt about Iran and the Middle East from Chomsky's London speech demonstrates, he rationally but aggressively debunks destructive mainstream falsehoods that huge numbers of people are taught to tacitly embrace. But all of that can be, and is, ignored in favor of hating his "style," ridiculing his personality, and smearing him with horrible slurs ("self-hating Jew").

What's particularly strange about this set of personality and style attacks is what little relationship they bear to reality. Far from being some sort of brutal, domineering, and angry "alpha-male" savage, Chomsky -- no matter your views of him -- is one of the most soft-spoken and unfailingly civil and polite political advocates on the planet. It's true that his critiques of?those who wield power and influence?can be withering -- that's the central function of an effective critic or just a human being with a conscience -- but one would be hard-pressed to find someone as prominent as he who is as steadfastly polite and considerate and eager to listen when it comes to interacting with those who are powerless and voiceless.?His humanism is legion. And far from being devoid of hope, it's almost impossible to find an establishment critic more passionate and animated when talking about the ability of people to join together to create real social and political change.

Then there's Edemariam's statement, offered with no citation, that Chomsky has been called "America's most prominent self-hating Jew" by the left-wing Nation magazine. This claim, though often repeated and obviously very serious, is inaccurate.

The Nation article which she seems to be referencing is not available online except by subscription. But what is freely available online is?a 1993 article on Chomsky from the Chicago Tribune?that makes clear that this did not come from the Nation itself, but from a single writer who, more importantly, was not himself calling Chomsky a "self-hating Jew" but was simply noting that this is?how he is often attacked?("one critic observed that Chomsky has 'acquired the reputation as America's most prominent self-hating Jew.'"). In 2010, the ?scholarly website 3 Quarks Daily?noted?an article on Chomsky from The Telegraph?that also claimed without citation that "the Left-wing Nation magazine [] called him 'America's most prominent self-hating Jew.'" Inquiries in the comment section for the source citation for this quote prompted this reply:

"I know this is a few years old, but the citation for the 'most prominent self-hating Jew' quote is: Morton, Brian. 'Chomsky Then and Now.' Nation 246, no. 18 (May 7, 1988): 646-652.

"With access to a full-text archive of The Nation, it took me only a few minutes to locate this. The full quote in context is 'If Chomsky has acquired the reputation of being America's most prominent self-hating Jew, this is because, in the United States, discussion about the Middle East has until recently taken place within very narrow bounds.'

"As you can see?the point was quite the opposite of how it was presented. The Nation often includes different perspectives so attributing one reviewer's comment to 'The Nation' as a whole would be dishonest anyway.

"Regardless of that however, the reviewer was actually making the point that Chomsky's views only seem far out because the spectrum is so limited. ... This is just another example of the kind of lazy, dishonest way in which Chomsky's views are generally reported."

Having myself retrieved?a full copy of Morton's 1988 article, I can say with certainty that this comment is indeed 100% accurate. Even leaving aside the sloppiness of attributing one article by a freelance writer to "the Nation" itself, it is wildly inaccurate -- on the substance -- to claim that the Nation labelled Chomsky a "self-hating Jew":

morton chomsky

The oft-repeated claim that Chomsky has "been called, by the Nation,?'America's most prominent self-hating Jew'" is simply false. If anything, that Nation article?debunked?that accusation, and certainly did not embrace it.

But the strangest attack on Chomsky is the insinuation that he has changed nothing. Aside from the metrics demonstrating that he has more reach and influence than virtually any public intellectual in the world, some of which Edemariam cites, I'd say that there is no living political writer who has more radically changed how more people think in more parts of the world about political issues than he. If you accept the premise (as I do) that the key to political change is to convince people of pervasive injustice and the need to act, then it's virtually laughable to depict him as inconsequential. Washington power-brokers and their media courtiers do not discuss him, and he does not make frequent (or any) appearances on US cable news outlets, but outside of those narrow and insular corridors -- meaning around the world -- few if any political thinkers are as well-known, influential or admired (to its credit, the Guardian, like?some US liberal outlets, does?periodically publish Chomsky's essays).

Like any person with a significant political platform, Chomsky is fair game for all sorts of criticisms. Like anyone else, he should be subjected to intense critical and adversarial scrutiny. Even admirers should listen to his (and everyone else's) pronouncements with a critical ear. Like anyone who makes prolific political arguments over the course of many years, he's made mistakes.

But what is at play here is this destructive dynamic that the more one dissents from political orthodoxies, the more personalized, style-focused and substance-free the attacks become. That's because once someone becomes sufficiently critical of establishment pieties, the goal is not merely to dispute their claims but to silence them. That's accomplished by demonizing the person on personality and style grounds to the point where huge numbers of people decide that nothing they say should even be considered, let alone accepted. It's a sorry and anti-intellectual tactic, to be sure, but a brutally effective one.

UPDATE

One of the passages from Edemariam's Guardian article that I quoted above has now been edited. The article originally stated: "Since then he has been accused of antisemitism (due to defending the right to free speech of a French professor who espoused such views, some 35 years ago)... " but has now been changed (with an editor's note appended to the bottom) as follows: "Since then he has been accused of antisemitism (due to defending some 35 years ago the right to free speech of a French professor who was later convicted of Holocaust denial)..." I note this to avoid any confusion, not because it affects any of the points I have raised here, especially the inaccurate attribution to the Nation as having called Chomsky a "self-hating Jew."

UPDATE II [Sunday]

The following editor's note has now been appended to Edemariam's Guardian article:

"This article was further amended on 24 March 2013. An incorrect reference to Chomsky having been called 'America's most prominent self-hating Jew' has been deleted. The error was the result of a quote being misconstrued."

That correction will hopefully put an end to this oft-repeated myth.

Source: http://www.opednews.com/articles/How-Noam-Chomsky-is-discus-by-Glenn-Greenwald-130324-786.html

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Monday, March 25, 2013

The drones are coming ... but our laws aren't ready

When a fire broke out in a church in Mesa County, Colo., in September 2011, the police department was ready with its flight team. Strapping a thermal camera to a Draganflyer X6, they flew the drone above the burning building. Together, police and firemen identified hotspots in the structure, and traced the direction in which the fire was spreading.

In 2010, a 5-pound Marcus drone was loaned to forest rangers in West Virginia by University Cincinnati researchers, in order to monitor a controlled burn. Now the group is developing an unmanned system to help control wildfires.

Even the Global Hawk, used by the U.S. Army, has entered civilian life. NOAA and NASA have decked two out with all kinds of sensors to watch storms as they brew. The crafts can endure (comparatively) long missions, letting researchers study large-scale weather patterns, like how grains from a Sahara sandstorm can seed a new hurricane when they reach the ocean.

There's no doubt drones can do a world of good. They can get to places humans can't, and do many jobs quicker ? for a fraction of the cost. Benjamin Miller, who manages the Mesa County Sheriff?s Office drone program, estimates that drones can do "30 percent of the missions of manned aviation for 2 percent of the cost." The two Mesa County drones cost $25 for each hour they are used.

But state-level bills cropping up across the U.S. could ground virtuous drones used in rescue and research. Meanwhile, privacy advocates and legal experts disagree over how effective the proposed legislation really will be.

In Oregon, one proposed bill requires that anyone who operates a drone, whether it's a local police department or a hobbyist, get a license from the Oregon Department of Aviation first.

An Indiana state bill wouldn't let a news station survey traffic on a highway, or let law enforcement send out an unmanned search party for lost hikers, the American Civil Liberties Union's Allie Bohm explained to NBC News. And a Nebraska bill wouldn't allow law enforcement to gather evidence or information via drone except in the case of a terrorist threat.

Two bills on the governor's desk in Virginia propose drone restrictions, but exclude select cases, such as search and rescue. Same for a bill proposed in Massachusetts last December, which would require police to get a warrant before sending a drone to collect aerial photography or thermal data as part of a criminal investigation.

Privacy advocates told NBC News they support this type of drone law.

"With drones, we have arrived at a moment when it is technologically possible to engage in constant mass aerial surveillance," the ACLU's Jay Stanley told NBC News. But don't surveillance cameras do some of that already? "We don't like those either," Stanley added, "But I think that drones raise the stakes considerably from there."

There's currently a trade-off between how maneuverable a drone can be and how long it can stay in the air. You can't combine the endurance of the solar-panelled QinetiQ Zephyr ? which stayed aloft in the Nevada desert for two straight weeks, but whose view can be blocked by clouds ? with the steady gaze of the Pentagon?s 1.8-gigapixel drone camera. Not yet.

One drone that captured the attention of Wednesday's senate hearing was AeroVironment's Nano Hummingbird, which can fly sideways or vertically by flapping two tiny wings. It weighs less than a AA battery, but records video. Not especially well, mind you, but cameras are always improving.

Regardless of current limitations, drones great and small still give law enforcement more reach than it had before. Yet while new legislation will surely be required, existing law may address some concerns.

"I believe that existing frameworks will provide more protection than is generally appreciated," John Villasenor a policy expert with UCLA and the Brookings Institution, told NBC News via email. By that he means that, when drones start snooping, courts will uphold certain privacies thanks to the Fourth Amendment.

Others say that current laws may be insufficient, but targeting drones misses the point.

?Whether data's being collected by Google or from cellphones or bank cameras or traffic cameras, I don't think the medium is the essence," Michael Toscano, president of the Association for Unmanned Vehicle Systems International, which represents drone manufacturers, told NBC News. "The question is what's being done with it, who's using it, who's collecting it, where's it being stored, where is it being deleted."

Toscano's organization may wish to keep drones out of legislation, but legal experts agree with the premise.

"Privacy law is not keeping up with surveillance technology, and drones are helping us see that," Ryan Calo, assistant professor of law at the University of Washington told NBC News. "But it's not limited to drones," he said, citing street cameras and vans like the ones driven by Google's mapping team.

"I think the good reason to get the privacy laws right here is to avail ourselves of this kind of technology," Calo said. And there's no time like the present, as the FAA has been asked to fully integrate drones into U.S. airspace by 2015.

More on drone policies: Lawmakers voice concerns on drone privacy questions

Nidhi Subbaraman writes about technology and science. Follow her on Twitter and Google+.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29ebe35d/l/0L0Snbcnews0N0Ctechnology0Ctechnolog0Cdrones0Eare0Ecoming0Eour0Elaws0Earent0Eready0E1C90A0A6243/story01.htm

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Wednesday, March 13, 2013

The Slate Desktop

The Slate Desktop We've seen our share of stunning wallpapers, packed-in widgets and skins, and desktops brimming with tweaks and customizations, but sometimes it's nice to see someone step back and say "these are the tools that work best for me, and that's all I need." Reader SARodrigues did just that with this desktop that's both clean and useful.

If you want the same look for your Windows desktop, you won't need much to make it happen:

Every now and again it's nice to see a Rainmeter setup that doesn't require a ton of skins and configuration and is suitable for just about any system, especially if you're just getting your toes in the water customizing your system to work the way you want it, as opposed to the way it's handed to you. If you need help with Rainmeter, we have a guide for that, or you can hop over to the original thread in our #featured-desktop forum to ask how SARodrigues how he set it all up!

Do you have a good-looking, functional desktop that you want to see featured here? Submit it?along with where you got the wallpaper, skins, and geeklets?to us for review. We have two different ways you can share it with us:

Linux, Mac, Windows, all are welcome. Whatever you choose to use, include a description of how you made your desktop when you send it in. Without that, we can't tell others how to make it for themselves so they can be featured too!

Original Thread via #featured-desktop

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ny9YhMcL1I8/the-slate-desktop

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